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Using Ivermectin for Demodectic Mange, Explained


Source: Flickr

Ivermectin is one of the few medicines that vets regularly prescribe for dogs with demodectic mange. The drug is easy to administer, and results are usually seen within a short period of time. It’s been proven many times over that Ivermectin is successful in curing the skin problem, but that doesn’t mean it can be considered as the de-facto solution for it.

The problem with Ivermectin is that it’s not the wonder drug most people think it is. Yes, it does seem to get rid of the mange, but it’s only a temporary solution at best. And that’s not to mention the various negative side-effects that can result from its use, some of which can even prove fatal.

How do you know if Ivermectin is the right type of treatment for your dog? Here are a few questions you should ask to help you decide.

What is Ivermectin?

Simply put, Ivermectin is an active ingredient in several medicines, specially designed for getting rid of parasites on a body. In the pet world, these are available in several products meant for different animals, like horses and dogs.

For dogs, two of the most popular products are ‘Ivomec’ or ‘Heartgard’, both of which are marketed as parasite control drugs. They affect skin parasites and several others that inhabit the bloodstream of the dog, such as heartworms. Incidentally, it is also used to prevent heartworm infestations in dogs as well, although that’s not its primary purpose.

How is it administered?

Ivermectin is usually produced in liquid or tablet form, which are administered to dogs orally – that is, the dogs are fed the drug.

The dosage measurements vary for each dog, determined by their weight. Usually the vet will provide the appropriate dosage, but generally speaking, a dose of 0.3mg/kg once every two weeks is sufficient for the treatment of demodectic mange. The liquid version of Ivermectin is sometimes packaged in filled syringes with set amounts, which makes it easier to gauge the dosage levels.

How does Ivermectin work?

Once it is administered to the affected dog, Ivermectin enters the bloodstream, using it as a means to affect the demodex mites in contact with the dog’s skin.

Picture of a Demodex Mite. If you look closely, you can see the legs resembling a catapillar. Ew!

Picture of a Demodex Mite. Source: Wiki Commons

From that point onwards, the drug does two things: Firstly, it disables the nervous systems of the mites, effectively paralysing them. Then, it manipulates the dog’s white blood cells into attacking the mites and killing them. In this way, the mites will no longer cause further skin damage to the dog’s body. So long as the drug remains in the body, the demodectic mange will be kept away indefinitely.

A minor note about Ivermectin: it doesn’t affect unhatched demodex mites still in their eggs. Therefore, more than one dose of Ivermectin is required to completely eradicate the mites from the body.

Advantages of using Ivermectin

Ivermectin has actually been proven to be capable of destroying the mites efficiently, which is why vets are still recommending it as their first choice in treating demodectic mange.

The drug is also very easy to administer, since they’re designed to be ingested orally and not given in the form of injections. This removes any effort required to calm the dog, since an injection can be a stressful experience.

Lastly, Ivermectin is relatively safe when used responsibly. This requires the vet and the owner to fully understand the dog’s condition and to adapt the treatment accordingly. If extensive care and caution is exercised, Ivermectin should not cause any trouble in the short-term.

Disadvantages of using Ivermectin

So far, Ivermectin seems like the perfect method of demodectic mange treatment; it’s safe, easy to use and most of all, it’s effective. In spite of all this, however, there are still a few disadvantages of using Ivermectin that should be highlighted:

1.)    It only solves half the problem. As we’ve said before, the purpose of Ivermectin is to kill off the mites that are causing demodectic mange to happen. However, that only settles part of the equation. The true key to stopping demodectic mange is to repair and rebuild your dog’s immune system, because it’s the only thing that can stop the demodex mites from appearing again. Even if all the mites are killed in one go (which is impossible, due to Ivermectin being unable to affect unhatched mites), the weak immune system will always be unable to prevent the mites from causing demodectic mange in future.

Source: Flickr

2.)    Reliance on Ivermectin. This is somewhat related to the first point. Some owners may discover by themselves that the drug is indeed a short-term solution; once the treatment stops for the affected dog, the mange might come back. Because the immune system wasn’t strong enough to handle the mites on its own before the Ivermectin was withdrawn, it still remains vulnerable to another attack and may cause a relapse.

At this point, the owner can pursue two options: keep the Ivermectin flowing to shut the mites out permanently using chemical drugs, or start building up the immune system to help the dog to recover on its own. Unfortunately, some owners choose the first option and suddenly find themselves spending a lot more in pet medical bills, just to keep the problem from spreading.

Besides the increased expenses, depending on Ivermectin as a long-term solution can also cause the immune system to ‘slack off’, letting the drug do all the work. When the Ivermectin doses eventually cease (which it eventually will), the dog will be essentially defenceless against the mites because its immunity is non-existent. The demodectic mange will most definitely reappear with a vengeance then.

3.)     Possible allergies to Ivermectin. This drug may be the default treatment recommended by vets to treat demodectic mange, but Ivermectin should never be given to some dogs due to possible allergic reactions.

Border collies and other herding breeds in particular are highly allergic to Ivermectin; a relatively low dose for another dog may be too much for a collie, and will cause severe side-effects such as lethargy, dehydration and even death.

Most people know about this innate allergy and will keep their dog away from the drug, but it actually isn’t as widely known as it should be. Some professional vets may not even know that a border collie shouldn’t receive a Ivermectin dose!

4.)    Long term use may cause liver damage. This is another reason why Ivermectin should not be given over a long period of time. While relatively harmless when used as a temporary solution, the drug may cause damage to the liver when administered long term. It’s important to remember that Ivermectin is primarily a pesticide for use against parasites, which means that it’s essentially a type of poison. Giving your dog Ivermectin for a year straight may hurt your dog as well.


Ivermectin is used to cure demodectic mange by killing the mites, and it does its job very well. The problem only starts when dog owners and even vets start treating it as a wonderdrug due to a lack of understanding, and depend on it exclusively.

The one thing that you should know is that Ivermectin only solves the problem of a mite overpopulation on your dog’s body as long as it’s being administered; the mites will return as soon as it stops and will start the cycle all over again. The mange will only clear up if the mites are denied the chance to spread, and the only thing that can do that is the immune system of the dog. Unfortunately, the Ivermectin does nothing to help in that regard.

The only other way to control the mites is through continuous use of Ivermectin, but as we have discovered earlier on in this article, it’s definitely not a feasible treatment plan for your dog.


Ivermectin is only one method of treating demodectic mange, and it’s definitely not meant for long-term use. If you’re looking for a safer and more effective alternative, why not take a look at some home remedies instead?

Click here to learn more about how to treat your dog’s skin problem the right way.

Related posts:

  1. Demodectic Mange Treatments Overview: Vet Approved Medicines
  2. Demodectic Mange Treatments: A Basic Overview
  3. Demodectic Mange: 4 Questions You Need To Ask
  4. Does Your Dog Have Demodectic Mange? 5 Ways To Identify The Symptoms
  5. Dog Mange: Why Bugs Are Mean

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